Obesity and susceptibility to severe outcomes following respiratory viral infection
Identifieur interne : 001440 ( Main/Exploration ); précédent : 001439; suivant : 001441Obesity and susceptibility to severe outcomes following respiratory viral infection
Auteurs : Mark H. Almond [Royaume-Uni] ; Michael R. Edwards [Royaume-Uni] ; Wendy S. Barclay [Royaume-Uni] ; Sebastian L. Johnston [Royaume-Uni]Source :
- Thorax [ 0040-6376 ] ; 2013-07.
Descripteurs français
- KwdFr :
- Facteurs de risque, Flambées de maladies, Humains, Infections communautaires (), Infections communautaires (virologie), Infections communautaires (épidémiologie), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Infections de l'appareil respiratoire (étiologie), Maladies virales (), Maladies virales (virologie), Maladies virales (épidémiologie), Morbidité (tendances), Obésité (), Obésité (épidémiologie), Santé mondiale.
- MESH :
- tendances : Morbidité.
- virologie : Infections communautaires, Infections de l'appareil respiratoire, Maladies virales.
- épidémiologie : Infections communautaires, Infections de l'appareil respiratoire, Maladies virales, Obésité.
- étiologie : Infections de l'appareil respiratoire.
- Facteurs de risque, Flambées de maladies, Humains, Infections communautaires, Maladies virales, Obésité, Santé mondiale.
English descriptors
- KwdEn :
- Community-Acquired Infections (complications), Community-Acquired Infections (epidemiology), Community-Acquired Infections (virology), Disease Outbreaks, Global Health, Humans, Morbidity (trends), Obesity (complications), Obesity (epidemiology), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (etiology), Respiratory Tract Infections (virology), Risk Factors, Virus Diseases (complications), Virus Diseases (epidemiology), Virus Diseases (virology).
- MESH :
- complications : Community-Acquired Infections, Obesity, Virus Diseases.
- epidemiology : Community-Acquired Infections, Obesity, Respiratory Tract Infections, Virus Diseases.
- etiology : Respiratory Tract Infections.
- trends : Morbidity.
- virology : Community-Acquired Infections, Respiratory Tract Infections, Virus Diseases.
- Teeft :
- Airway disease infection section, Almond, Antiviral, Asthma, Attenuated, Brief synthesis, Chest clinic, Clinical infections, Cytokine, Disease Outbreaks, Disease severity, Global Health, Humans, Ifns, Immunomodulatory, Immunomodulatory effects, Imperial college london, Independent risk factor, Infection, Interferon, Leptin, Lung institute, Mechanisms underpinning, Molecular patterns, Mrna expression, Multiple markers, National heart, Numerous nosocomial, Obese, Obese individuals, Obesity, Pandemic, Pandemic infection, Particular focus, Poor outcomes, Potential mechanism, Recent advances, Receptor, Rhinovirus, Rhinovirus infection, Risk Factors, Severe outcomes, Thorax.
Abstract
During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.
Url:
DOI: 10.1136/thoraxjnl-2012-203009
Affiliations:
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xml:lang="fr"><term>Facteurs de risque</term><term>Flambées de maladies</term><term>Humains</term><term>Infections communautaires</term><term>Maladies virales</term><term>Obésité</term><term>Santé mondiale</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Almond, Mark H" sort="Almond, Mark H" uniqKey="Almond M" first="Mark H" last="Almond">Mark H. Almond</name></noRegion><name sortKey="Almond, Mark H" sort="Almond, Mark H" uniqKey="Almond M" first="Mark H" last="Almond">Mark H. Almond</name><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S" last="Barclay">Wendy S. Barclay</name><name sortKey="Edwards, Michael R" sort="Edwards, Michael R" uniqKey="Edwards M" first="Michael R" last="Edwards">Michael R. Edwards</name><name sortKey="Johnston, Sebastian L" sort="Johnston, Sebastian L" uniqKey="Johnston S" first="Sebastian L" last="Johnston">Sebastian L. Johnston</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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